![]() ![]() A modest number of participants were enrolled, with crossover of the injection schedule (morning to evening or vice versa), so group size was limited, with a low power to detect differences between treatments-that is, the percentage of time within the glucose range of 80–140 mg/dL (the primary end point), glucose variability metrics, and post hoc analyses. This study also used a short duration of treatment (two 8-week periods), although a 2-week period of CGM (weeks 7–8 in this study) is considered to be representative of the longer-term pattern of glucose levels ( 17). Future studies could be enhanced by using the recently approved Gla-300 pen injector the use of syringes with Gla-300 might be expected to increase glucose variability in the Gla-300 group, although an increase in variability was not seen in this study. This exploratory CGM study has limitations: the open-label study design, which was unavoidable because of the different injection volumes of Gla-300 and Gla-100, and the use of commercial syringes that are not approved for use with Gla-300 in clinical practice and are suboptimal for delivery of an insulin with a concentration of 300 units/mL. In the current study, however, mean 24-h glucose profiles do not provide any indication of glucose levels being higher with Gla-300 than with Gla-100 at a time that might be considered “before breakfast.” In addition, the hypoglycemia results presented here could be influenced by the fact that mean interstitial glucose levels were higher with Gla-300 than Gla-100 at baseline, although this was likely offset by the greater decrease in glucose over the study period with Gla-300 and the lower final mean glucose in that group. ![]() The phase IIIa EDITION 4 study also investigated Gla-300 versus Gla-100 in people with type 1 diabetes and observed an increase in SMPG with Gla-300 before breakfast in the initial weeks of the study that might have affected the risk of hypoglycemia. There were no consistent within-treatment differences in terms of hypoglycemia risk between the morning and evening injection groups for either of the insulin preparations. During the nocturnal period, mealtime insulin would be expected to have minimal effect as a contributory factor, allowing a more reliable comparison of the effects of basal insulin. The annualized event rates for SMPG-confirmed or severe hypoglycemia were lower in the Gla-300 than Gla-100 group during the nocturnal period (0000–0559 h), which showed a risk reduction of 55% for confirmed (<54 mg/dL) or severe hypoglycemia. Rates of hypoglycemia detected using SMPG values were consistent with the interstitial glucose values detected by CGM. While glucose variability metrics were smaller for Gla-300 than Gla-100, consistent with the 24-h glucose profiles, there were no statistically significant differences in these metrics. The increase in glucose levels from 0200−0800 h in the Gla-100 morning injection group may be more pronounced than any glucose increases seen in the evening injection group as a result of the basal insulin waning toward the end of the 24-h dosing interval, which is not masked by the use of rapid-acting insulin during this early morning period. This difference in profile was even more evident when morning and evening injection groups were compared the glucose profiles of Gla-300 morning and evening injections are nearly superimposable, whereas larger excursions were seen in the morning injection group compared with the evening injection group for Gla-100. The mean 24-h glucose profile, averaged for all participants on CGM in each group by time of day, showed a narrower range of daily interstitial glucose levels for Gla-300 than for Gla-100. However, only a small percentage of individuals with type 1 diabetes who use these first-generation analogs achieve glycemic targets, and excursions into clinically dangerous hypoglycemic and hyperglycemic states are common ( 12). The first generation of basal insulin analogs have substantially improved glucose management, offering a prolonged duration of action and a lower risk of hypoglycemia, particularly overnight, compared with NPH insulin ( 11). The basal insulin can then be paired with a rapid-acting insulin before a meal that is adjusted to optimize glycemic control after the meal ( 10). To achieve this, the “ideal” basal insulin should provide stable glucose-lowering activity over an entire 24-h period and help maintain target glucose levels in the fasting state and before meals ( 9). A fundamental goal of type 1 diabetes management is to maintain glucose levels within a target range and to minimize vulnerability to hypoglycemic or hyperglycemic events that can lead to short- and/or long-term health complications ( 6– 8).
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One of the best features of MaxBulk Mailer is the set-up/installation options. Start Download (Direct Link) Free Download MaxBulk Mailer Pro 8.8.3 Full Version ![]() Over the following four years, the expedition mapped much of the continent’s coastline, located the south magnetic pole, named an active volcano Erebus, catalogued a plethora of animals and enough plants to provide the assistant surgeon, Joseph Hooker (he of the introductory stockings), with the 3,000 specimens that provided the basis for his classic six volumes of Flora Antarctica. After replenishing in Van Diemen’s Land (Tasmania), where John Franklin was Lieutenant Governor, they set off to explore Antartica. On both occasions she was accompanied by Terror under the command of Ross’ close friend Francis Rawdon Moira Crozier. The rest of the book is divided into two sections covering Erebus’s two great voyages: Ross’ four year exploration of the Antarctic and Franklin’s tragic attempt to transit the Northwest Passage. We learn about the early expeditions and through this are introduced to the two main characters in the Erebus story, James Clark Ross and John Franklin. Most importantly, Palin cunningly sidesteps the issue of having his book undermined by the next dive on the wrecks: instead of focussing on the expedition, Palin gives us a biography of one of the ships.Īfter a short introduction with a title that could be out of Monty Python-"Hooker’s Stockings"-Palin gets down to business with a concise section outlining the construction of HMS Erebus in the Pembroke dockyards in Wales and the development of British interest in the ends of the earth after the Napoleonic wars. ![]() Palin’s book is not - at least yet - dated it is very well written and only weird where the author wishes it to be. The hundreds of artifacts and the possibility of written records preserved in the cold water offer the chance of discovering more about the expedition at one fell swoop than many lifetimes of dedicated researching have previously done. Suddenly, the risk of almost anything written about the Franklin disaster becoming outdated or being proven wrong overnight mushroomed. Then the lost ships were discovered, Erebus in 2014 and Terror two years later. As Canada’s national interest in the Arctic grew in the second half of the 20th century, so the mystery of Franklin’s fate revived, fuelled by Owen Beattie’s work on the bodies buried at Beechey Island and the politics of sovereignty. There was a palpable sense of closure.” The skeleton of the story was known in as much detail as was possible, the memorialization could progress and for a century little was discovered to disturb the narrative. Many are stylistically dated or poorly written or just plain weird, but for anyone wanting to add to the corpus of Franklin literature today, there is a much more dangerous pitfall-time.Īs Michael Palin puts it in Erebus, after Lieutenant Schwatka’s return from his exploration of King William Island in 1880, “The indignation that fuelled the search, the wounded national pride that gave it such imperative, and the appetite of newspapers…for the grisly details had all diminished. In the past century and a half, dozens of books have been published dealing with the lost Franklin Expedition but only a few have stood the test of time-springing to mind are Richard Cyriax’s magisterial Sir John Franklin’s Last Arctic Expedition and David Woodman’s examination of the Inuit testimony, Unravelling the Franklin Mystery. Toronto: Penguin Random House Canada CDN $37 Erebus: One Ship, Two Epic Voyages, and the Greatest Naval Mystery of All Time I have to keep a close watch at Wally World….it appears Wally World here gets 1lb containers or Varget more than any other powder outside of Unique. MidSouth Shooters has Remington primers as I type and various powder mostly Norma powders. Natchez Shooters Supplies has various CCI…some Federal…some Tula primers plus various powdersģrd Generation Shooting Supply has Winchester small and large rifle and pistol and various powders. Happy loading, Buy CCI Large Rifle Primers Have a link to share? Please leave a comment! Now, if I could just find 8lb cannisters of Hodgdon Varget! ( this link will show you primer categories that are in stock).īallistic Products has primers in stock! Included are CCI small pistol (on sale!), Winchester large rifle, Federal small pistol match, Federal small pistol, and Winchester large rifle magnum. ![]() Widener’s also has some primers available, including Sellier & Bellot large rifle and large rifle magnum, various types CCI primers (small pistol APS, large rifle APS, small rifle magnum APS)īrownells has Winchester large rifle magnum, CCI 50 cal, Remington small pistol magnum, and Remington large rifle magnum. MidwayUSA has quite a few primers in stock ( this link will show you all that are available) including small pistol, large pistol, small rifle, and large rifle (and large rifle magnum, small pistol magnum). Federal primers are still out of stock, but there are some primers available, including Tula small rifle primers, Winchester large rifle and large rifle magnum. Powder Valley is now processing orders within 3 days of placement! This is down from a month I can recall earlier this year. Hopefully this is a sign of things becoming less scarce! ![]() Hey everyone, I know it’s been a HUGE challenge to find primers lately, so I thought I’d send some links to online sources that have primers in-stock. ![]() This formula produces the discrepancy between the 227 levels and the 128,016,000 (the least common multiple of 125, 126, 127, and 128) stages. If the level number is N, then the top-right segment is (N-1)%128, the bottom-right is (3N-2)%127, the top-left is (5N-3)%126, and the bottom-left is (7N-4)%125, where %n means remainder after division by n. The layout of each segment is determined from a master list of 128 set layouts (numbered 0 to 127) based on a linear congruence using the level number. ![]() Each level is a 32x32 wrapping square (torus) that consists of four 16x16 segments. These levels are not unique in their design. These 3D stages place Sonic on a grid, where his movement is restricted to simple turns. After level 134,217,728, however, the level number resets too. Hidden behind every Star Post in Sonic Mania are 32 different Blue Sphere stages. In the Special Stages, the blue Spheres fill a gauge at the top of the screen that represents the player's Mach speed. Genesis / 32X / SCD - Sonic & Knuckles - Get Blue Spheres Title Screen & Results (Lock-On) - The 1 source for video game sprites on the internet In the next couple of hours, the server will be going down to prepare for a transfer to our new servers. After 128,016,000, the stages repeat, even though the level number continues to advance. Spheres reappear in Sonic Mania and its expansion Sonic Mania Plus, both for Special Stages and Bonus Stages. In fact, there are actually only 128,016,000 distinct level layouts (or stages). (Note, as mentioned above, collecting every ring and scoring a perfect allows players to advance ten levels.) Once a player reaches the final level, the sequence repeats from the beginning. Is there an analysis video or behind the scenes for blue spheres? This is very interesting to me.īlue Sphere has 134,217,728 (227) levels, which are played in sequence. ![]() No comic book character is 100 percent original. “I once saw a guy on Instagram with a tiger tattoo, and he did a Photoshop effect where he pulled the tiger off. ![]() “Blasted is based on Acat of Mayan mythology,” Sands says. He can manipulate the ink from his tattoos to turn the images on his body into weapons. Blasted’s main superpower is called melanokinesis. “True comic book fans eat that stuff up, and if Sacramento residents see something familiar in the books, then that’s even better.”īlasted is his newest superhero and was born and raised in Stockton. “I love dropping Easter eggs into my work,” Sands says. Brooke is the first name of Sands’ sister, and Bolton is an homage to Ruthie Bolton, the Sacramento Monarchs’ most famous player. Superhero strong, she can fly and control cosmic energy. Lady Monarch is the alter ego of Brooke Bolton, a social media influencer who discovers she is the reincarnated Egyptian goddess Ma’at. The book’s logo is scripted in the font used by the defunct Sacramento Monarchs WNBA team, although the main character has nothing to do with basketball, Sands says. The “Lady Monarch” series also takes place in Sacramento the cover of the debut book features the titular superheroine sitting on Tower Bridge. Everyone else is either an anti-hero or true villain.” Lady Monarch is true blue and Blasted is more on the true-blue end. I don’t have too many ‘true blue’ heroes. He’s got a lot of rage, and if you’re in his way, you’re probably going to die. Impound is more like (Marvel’s violent vigilante) Punisher, more of an anti-hero, especially in the more recent books. ![]() “He’s pretty much a melting pot of my favorite things. “Impound was pulled from Spawn (Image Comics) and ‘Mortal Kombat’ (video game and movie), and ‘Pulp Fiction’ was a big inspiration on this story, too,” Sands says. Sands has branched out with five additional comic book series, featuring characters with names such as Lady Monarch, Blasted and Decymus. The rest of the story line features Impound developing his powers to avenge what Jones and others have done to him. That incurs the wrath of a Sacramento crime lord named Christ Jones, who exacts his revenge by attacking Impound’s family. Without spoiling too much of the origin story in Impound #1, Endsley is offered money to take a dive in an MMA fight but instead beats the local champion. His first comic book series, Impound, is based in Sacramento and centers around Anthony “Impound” Endsley, a tow-truck driver by day, an amateur mixed martial arts fighter by night trying to make it to the Ultimate Fighting Championship. “I need more people to see it, so I took the leap.” “If this whole thing is going to become what I want it to be, then I had to make the move,” Sands says. In April, Sands took another leap to expand the brand, hiring more employees to run the DOCO store so he could move to Hollywood and be closer to publishers, television and animation studios, and merchandising experts. “They were like, ‘We’re willing to take a risk on your company because we think you have something that could eventually become a Sacramento touristy thing.’ It makes sense in DOCO, and for the Sacramento Kings, to have a Sacramento superhero. When I started, I didn’t have that many books, but believed in the vision,” Sands says. “That agreement is helping me grow the brand. Brent Trayce Sands’ first comic book series is based in Sacramento and centers around Anthony “Impound” Endsley, a tow-truck driver by day, an amateur mixed martial arts fighter by night. That’s allowed him to focus on expanding his comics universe rather than just growing the bottom line. Sands, 34, says he has a business agreement with DOCO operator CBRE, which takes a percentage of sales in lieu of a traditional leasing agreement. Impound Comics sells only the series created by Sands, while his Arden Fair store is more of a traditional comic book store that sells books from the major publishers such as Marvel, DC and Image, plus toys, game cards and other merchandise. The business is growing as fast as the superpowers of his characters-so much so that Sands opened Anti-Hero in Arden Fair mall this past July. That number has now reached five, with a sixth coming in May. Yamasuki had just purchased the comic book from Brent Trayce Sands, who came up with the character and opened Impound Comics store in 2021 to feature his growing series of comic books. ![]() The formulation of i-pulse is done by the BIOACTIVES which is a Japanese company. It clearly signifies that I-pulse is a premium and high-quality product. The Ministry of AYUSH department has awarded I-pulse a premium certification due to its various Health Benefits. I-pulse can be safely consumed by people suffering from diabetes and hypertension. NASA has developed a space drink AS10 which has Acai berry as an active ingredient, this drink prevents the astronauts from various types of radiation and skin cancer.Īlong with all these benefits i-pulse provide a total of 26 major benefits to our bodyĦ0ml of I-pulse before 30 min of eating anything in the morning daily even before brushing the teeth.ģ0ml of i-pulse before 30 min of breakfast and 30ml of iPulse 30 min before dinner. ![]() It helps to prevent various types of cancer. The Acai berry which is an active ingredient of iPulse has various anticancer properties. Resveratrol is basically an extract of black grape seeds which helps to reduce cardiovascular problems. It improves the functioning of our heart. Resveratrol found in i-pulse is very good and useful for our heart. It neutralizes the free radicals and reactive oxygen species which slowdowns the ageing process. The blend of various types of fruits enriched with various types of antioxidants limits the various types of harmful effects of oxidative and also detoxifies our body. It provides essential fatty acids and essentials oil to our body which enhances the cellular communication between the body and builds proteins and also strengthens the nervous system. Also, it helps to reduce cholesterol and inhibits platelet aggregation. The various organic ingredients of I-pulse help to strengthen the organs of the body like eyes, liver, kidneys etc and it helps in the digestion of food. It protects the cells of our body and strengthens the cell membranes. The intake of 60ml of I-pulse provides the 7000ORAC value of antioxidants to our body. A normal person needs at least 5000 ORAC values of antioxidants in daily life whereas a diseased person needs even more. To combat this oxidative stress our body needs adequate antioxidants. Which leads to aging, diabetes, obesity, cardiovascular disease or heart diseases, stroke, infertility, and cancer. To prevent this our body already has antioxidants but due to poor diet it leads to an imbalance between oxidants and antioxidants in our body and results in a condition called oxidative stress. The oxygen we intake in our body reacts and oxidates with our body. The i-pulse is highly rich in antioxidants. It means that it increases the power of the body to fight with various types of viruses and bacteria. ![]() The daily consumption of i-pulse helps to improve the immune system of our body. It is equal to 70 glasses of orange juice’s vitamin C and has an antioxidant value equal to 100 cups of green tea. The nutrition value of 60ml of i-pulse is equivalent to nutrition from 3.5kgs of fresh garden fruits and vegetables. There are lots of medicines in the market which provide us different kinds of minerals, vitamins, and nutrients which are necessary for our day to day life, but in the end, they are artificial and put some harmful impact on our health in long term. It is clear that one cannot eat 3.5 kgs of fruits and vegetables in his daily diet due to a tightly packed schedule and our bad craving for fast food. So, how to complete that amount of nutrients and antioxidants that we need in our diet. Fruitarian diet consists of a major proportion of diet in the form of fruits.īut the main problem is that the common and mostly middle-class people like us don’t believe in the fruitarian diet. Fruitarian diet is taken by very fewer people, we can see all of the famous Hollywood and Bollywood stars which prefer a fruitarian diet for their fitness. We all know that nature has provided us with three types of Diets (vegetarian, nonvegetarian, and fruitarian). 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